Gene information
Official symbol RET
Official full name ret proto-oncogene
Gene type protein-coding gene
Chromosome10q11.21
Alias symbolPTC; CDHF12; RET51; CDHR16
Previous symbolHSCR1; MEN2A; MTC1; MEN2B
Gene familyCadherin related; Receptor tyrosine kinases
Resources
Entrez Gene 5979
HGNC HGNC:9967
Ensembl ENSG00000165731
Vega OTTHUMG00000018024
UCSC uc001jal.4
GO terms: 119 records
GO Description Category LogP Number of genes Detail
GO:0000165 MAPK cascade GO Biological Processes -7.43732657 14 More
GO:0000902 cell morphogenesis GO Biological Processes -11.5134430 38 More
GO:0000904 cell morphogenesis involved in differentiation GO Biological Processes -8.70147397 29 More
GO:0001654 eye development GO Biological Processes -3.29977134 15 More
GO:0001655 urogenital system development GO Biological Processes -19.5104956 58 More
GO:0001656 metanephros development GO Biological Processes -4.52618369 8 More
GO:0001657 ureteric bud development GO Biological Processes -9.01105989 19 More
GO:0001667 ameboidal-type cell migration GO Biological Processes -17.0771232 40 More
GO:0001755 neural crest cell migration GO Biological Processes -8.06132628 15 More
GO:0001822 kidney development GO Biological Processes -16.2664835 49 More
GO:0001823 mesonephros development GO Biological Processes -9.38463473 20 More
GO:0001838 embryonic epithelial tube formation GO Biological Processes -6.74209917 20 More
GO:0002009 morphogenesis of an epithelium GO Biological Processes -21.4354199 71 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0004672 protein kinase activity GO Molecular Functions -2.03527804 36 More
GO:0004713 protein tyrosine kinase activity GO Molecular Functions -1.63313364 5 More
GO:0004714 transmembrane receptor protein tyrosine kinase activity GO Molecular Functions -3.13739094 5 More
GO:0005509 calcium ion binding GO Molecular Functions -14.7764642 80 More
GO:0005769 early endosome GO Cellular Components -6.25251045 19 More
GO:0006468 protein phosphorylation GO Biological Processes -5.36604576 56 More
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO Biological Processes -1.87488892 7 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007409 axonogenesis GO Biological Processes -2.66639313 13 More
GO:0007411 axon guidance GO Biological Processes -2.45312404 19 More
GO:0007423 sensory organ development GO Biological Processes -8.10586983 29 More
GO:0007494 midgut development GO Biological Processes -3.29594651 3 More
GO:0008361 regulation of cell size GO Biological Processes -4.6524989 21 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0010008 endosome membrane GO Cellular Components -3.11007663 16 More
GO:0010720 positive regulation of cell development GO Biological Processes -17.713649 52 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0010975 regulation of neuron projection development GO Biological Processes -5.89330331 41 More
GO:0010976 positive regulation of neuron projection development GO Biological Processes -4.13061709 18 More
GO:0014032 neural crest cell development GO Biological Processes -11.9399165 15 More
GO:0014033 neural crest cell differentiation GO Biological Processes -12.2997127 24 More
GO:0016331 morphogenesis of embryonic epithelium GO Biological Processes -7.49308957 23 More
GO:0018108 peptidyl-tyrosine phosphorylation GO Biological Processes -3.43405510 8 More
GO:0018212 peptidyl-tyrosine modification GO Biological Processes -3.37492500 8 More
GO:0019199 transmembrane receptor protein kinase activity GO Molecular Functions -5.31743835 14 More
GO:0021675 nerve development GO Biological Processes -3.85527067 12 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030424 axon GO Cellular Components -6.14132550 54 More
GO:0030425 dendrite GO Cellular Components -4.55233052 48 More
GO:0031175 neuron projection development GO Biological Processes -7.36986002 58 More
GO:0031344 regulation of cell projection organization GO Biological Processes -8.91314416 62 More
GO:0031346 positive regulation of cell projection organization GO Biological Processes -6.78114948 37 More
GO:0032535 regulation of cellular component size GO Biological Processes -4.60941253 33 More
GO:0032989 cellular component morphogenesis GO Biological Processes -4.92421328 47 More
GO:0032990 cell part morphogenesis GO Biological Processes -4.32681114 20 More
GO:0033135 regulation of peptidyl-serine phosphorylation GO Biological Processes -8.68560410 14 More
GO:0033555 multicellular organismal response to stress GO Biological Processes -7.79385832 16 More
GO:0033619 membrane protein proteolysis GO Biological Processes -2.50832748 6 More
GO:0033628 regulation of cell adhesion mediated by integrin GO Biological Processes -4.66823778 6 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0035148 tube formation GO Biological Processes -7.32029616 23 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042551 neuron maturation GO Biological Processes -3.82142288 8 More
GO:0043010 camera-type eye development GO Biological Processes -3.41918860 14 More
GO:0043025 neuronal cell body GO Cellular Components -9.18558636 52 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043235 receptor complex GO Cellular Components -19.4198369 40 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044297 cell body GO Cellular Components -11.7206640 62 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045664 regulation of neuron differentiation GO Biological Processes -9.07830873 18 More
GO:0048265 response to pain GO Biological Processes -4.73205562 8 More
GO:0048483 autonomic nervous system development GO Biological Processes -4.59833472 10 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0048565 digestive tract development GO Biological Processes -11.5666667 27 More
GO:0048598 embryonic morphogenesis GO Biological Processes -22.1253699 83 More
GO:0048667 cell morphogenesis involved in neuron differentiation GO Biological Processes -4.77475952 19 More
GO:0048729 tissue morphogenesis GO Biological Processes -31.7796969 96 More
GO:0048762 mesenchymal cell differentiation GO Biological Processes -16.1250183 37 More
GO:0048812 neuron projection morphogenesis GO Biological Processes -4.67859800 20 More
GO:0048858 cell projection morphogenesis GO Biological Processes -4.57120185 20 More
GO:0048863 stem cell differentiation GO Biological Processes -16.2106470 36 More
GO:0048864 stem cell development GO Biological Processes -12.7283120 16 More
GO:0048880 sensory system development GO Biological Processes -3.47450215 31 More
GO:0050770 regulation of axonogenesis GO Biological Processes -3.56457741 17 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051897 positive regulation of protein kinase B signaling GO Biological Processes -23.7578366 39 More
GO:0055123 digestive system development GO Biological Processes -12.1524002 29 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060384 innervation GO Biological Processes -3.21663541 6 More
GO:0060485 mesenchyme development GO Biological Processes -18.0238 46 More
GO:0060562 epithelial tube morphogenesis GO Biological Processes -17.7630248 53 More
GO:0061564 axon development GO Biological Processes -3.13387450 15 More
GO:0071300 cellular response to retinoic acid GO Biological Processes -4.69230219 12 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0072001 renal system development GO Biological Processes -17.7796243 52 More
GO:0072073 kidney epithelium development GO Biological Processes -9.16824163 24 More
GO:0072163 mesonephric epithelium development GO Biological Processes -8.91550162 19 More
GO:0072164 mesonephric tubule development GO Biological Processes -8.91550162 19 More
GO:0072175 epithelial tube formation GO Biological Processes -6.28242122 20 More
GO:0072215 regulation of metanephros development GO Biological Processes -4.49239295 3 More
GO:0072676 lymphocyte migration GO Biological Processes -7.69367801 10 More
GO:0090066 regulation of anatomical structure size GO Biological Processes -32.7608623 52 More
GO:0090183 regulation of kidney development GO Biological Processes -5.21154381 9 More
GO:0090497 mesenchymal cell migration GO Biological Processes -8.76593708 16 More
GO:0097447 dendritic tree GO Cellular Components -4.82959150 49 More
GO:0097485 neuron projection guidance GO Biological Processes -2.79075716 20 More
GO:0098609 cell-cell adhesion GO Biological Processes -15.7963965 69 More
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO Biological Processes -5.22391282 28 More
GO:0098797 plasma membrane protein complex GO Cellular Components -14.6387951 39 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0120035 regulation of plasma membrane bounded cell projection organization GO Biological Processes -8.54789693 60 More
GO:0120039 plasma membrane bounded cell projection morphogenesis GO Biological Processes -4.62455556 20 More
GO:0150063 visual system development GO Biological Processes -3.59465978 31 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2001235 positive regulation of apoptotic signaling pathway GO Biological Processes -13.4065813 30 More
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway GO Biological Processes -7.00132107 13 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa04020 Calcium signaling pathway KEGG Pathway -10.4415222 36 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
Drug-Gene interaction
view
Related drugs: 62 records
Drug name Interaction type Source PMID View
alectinib JAX-CKBCIViC 27544060 view
alectinib hydrochloride inhibitor ChemblInteractions view
alisertib DTC view
amuvatinib inhibitor TALCMyCancerGenomeTdgClinicalTrial view
ast-487 inhibitor DTCChemblInteractionsCIViC 23828865 view
at-9283 inhibitor TALC view
azd-1152-hqpa DTC view
azd-1480 JAX-CKB 23056499 view
barasertib DTC view
cabozantinib inhibitorantagonist TALCMyCancerGenomeJAX-CKBCIViCMyCancerGenomeClinicalTrialPharmGKBFDAOncoKB 25366691800723533264172160641223584301237059462844791227525386278256362015 view
cediranib DTC view
cenisertib DTC view
cep-2563 inhibitor ChemblInteractions view
cep-32496 inhibitor JAX-CKBChemblInteractionsCIViCTTD 2801146129538669 view
cetuximab JAX-CKB 27149458 view
chembl1997335 DTC view
chembl202721 DTC view
chembl546797 DTC view
cyc-116 DTC view
dexamethasone NCI 10947080 view
dovitinib DTCClearityFoundationClinicalTrialJAX-CKB 25103625 view
enmd-2076 TdgClinicalTrial view
entrectinib DTC view
erlotinib DTC view
everolimus JAX-CKB 2629490827683183 view
genistein NCI 12490842 view
gw441756x DTC view
hesperadin inhibitor DTC 19035792 view
ilorasertib DTC view
imatinib inhibitor TdgClinicalTrialTEND 16782438 view
imatinib mesylate NCI 12490842 view
jnj-7706621 DTC view
lapatinib DTC view
lenvatinib inhibitor TALCJAX-CKBCIViC 252952142749613417943726 view
lestaurtinib inhibitor ChemblInteractions view
linifanib inhibitor DTCTdgClinicalTrial view
motesanib inhibitor TALCMyCancerGenomeJAX-CKBChemblInteractionsCIViC 21422803 view
osi-632 DTC view
palbociclib DTC view
pazopanib DTC view
pd-0166285 DTC view
pf-00562271 DTC view
ponatinib inhibitor TALCJAX-CKBCIViCMyCancerGenomeClinicalTrialTTD 27496134238112352512242723526464 view
pralsetinib inhibitor TTDOncoKB view
quizartinib inhibitor ChemblInteractions view
r-406 DTC view
regorafenib inhibitor TALCMyCancerGenomeJAX-CKBChemblInteractionsMyCancerGenomeClinicalTrialTTD 21170960 view
rg-1530 inhibitor DTC view
romiplostim TTD view
sapanisertib CIViC 23828865 view
sb-220025 DTC view
sitravatinib TTD view
sns-314 DTC view
sorafenib inhibitor DTCMyCancerGenomeJAX-CKBCIViCPharmGKB 20368568188499711766427317016424283627161546620616507829 view
sorafenib tosylate inhibitor ChemblInteractions view
sp-600125 DTC view
sunitinib inhibitor TALCMyCancerGenomeTdgClinicalTrialJAX-CKBNCITENDDoCMCIViCPharmGKB 1135125427149458206960542036856819255327185418941924897121455200168494189681850230564992202514620065189214228032515796820847059209437192844791298394971807330721470995 view
sunitinib malate inhibitor ChemblInteractions view
tae-684 DTC view
tanespimycin NCI 15302866 view
tozasertib inhibitor DTC 19035792 view
vandetanib inhibitor TALCDTCMyCancerGenomeTdgClinicalTrialClearityFoundationClinicalTrialJAX-CKBChemblInteractionsDoCMCIViCMyCancerGenomeClinicalTrialPharmGKBTTDOncoKB 113512541902922420368568192553271854189425366691800721455200235332641796818502443336123056499278256162202514620065189276831832780300521422803235843011059223525122427251579682084705915184865209437192844791298394971807330721470995266860642015 view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
NC_000010.11:g.43623658_43625593dul genomics myocardial infarction[diagnosis] myocardial infarction Shia WC et al. BMC Genomics. 2011
Chr10:42933638 hypomethylation epigenomics ischemic cardiac events[prognosis (bad)] myocardial infarction Thunders M et al. Epigenetics. 2019
All rights reserved: Soochow University Center for Systems Biology